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What is the history of Rheumatic Fever?
History of Rheumatic Fever: when and how it was discovered, and the milestones in research since, medically reviewed.
Translated from spanish
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Definition
Rheumatic fever (RF), caused by the immune response to the streptococcus, and continues to be a global health problem. It is a systemic inflammatory disease characterized by the presence of lesions that can affect the heart, joints, the nervous system, the skin and the subcutaneous tissue.
Pathogenesis
It affects mostly children between 5 and 15 years.
60% of individuals who present with acute rheumatic fever (ARF) will develop rheumatic heart disease. According to WHO data from 2004, 15.6 million people suffer from heart disease residual incidence is extremely variable according to whether developed countries or not, with highest incidence in Asia, Africa and South america.
Pathophysiology
In genetically predisposed individuals, the strep infection triggers an immune response that causes heart injury, joint, or brain. Is mediated by an immunological reaction. It has demonstrated the presence of antigenic determinants common between the streptococcus and the heart muscle, that suggest cross-reactivity.
The bodies of Aschoff are the characteristic of carditis. Occur inflammatory injury with subsequent fibrosis and calcification that lead to alterations in valvular insufficiency and stenosis.
Symptoms
Classically it is said that the FRA "licks the joints and bites the heart". The arthritis is migratory without sequelae, and cardiac involvement can cause lesions valvular chronic. The symptomatology is variable and can at times be very atypical, which makes it difficult to diagnosis.
Diagnosis
The diagnosis is based on criteria modified from Jones and WHO criteria. There is no pathognomonic test. In 1944 it introduced the criteria of Jones were updated in 1992 by the American Heart Association.
Prophylaxis and treatment
The prophylactic treatment is penicillin, which is essential to preventing heart disease. Penicillin remains the drug of choice to prevent infection, treat the inflammatory process and continue long-term prophylaxis.
Prognosis
Cardiac involvement will mark the long-term prognosis. Arthritis, chorea and cutaneous lesions are self-limited. The forecast is given by the degree of cardiac involvement and valvular lesions residual.
Rheumatic fever (RF), caused by the immune response to the streptococcus, and continues to be a global health problem. It is a systemic inflammatory disease characterized by the presence of lesions that can affect the heart, joints, the nervous system, the skin and the subcutaneous tissue.
Pathogenesis
It affects mostly children between 5 and 15 years.
60% of individuals who present with acute rheumatic fever (ARF) will develop rheumatic heart disease. According to WHO data from 2004, 15.6 million people suffer from heart disease residual incidence is extremely variable according to whether developed countries or not, with highest incidence in Asia, Africa and South america.
Pathophysiology
In genetically predisposed individuals, the strep infection triggers an immune response that causes heart injury, joint, or brain. Is mediated by an immunological reaction. It has demonstrated the presence of antigenic determinants common between the streptococcus and the heart muscle, that suggest cross-reactivity.
The bodies of Aschoff are the characteristic of carditis. Occur inflammatory injury with subsequent fibrosis and calcification that lead to alterations in valvular insufficiency and stenosis.
Symptoms
Classically it is said that the FRA "licks the joints and bites the heart". The arthritis is migratory without sequelae, and cardiac involvement can cause lesions valvular chronic. The symptomatology is variable and can at times be very atypical, which makes it difficult to diagnosis.
Diagnosis
The diagnosis is based on criteria modified from Jones and WHO criteria. There is no pathognomonic test. In 1944 it introduced the criteria of Jones were updated in 1992 by the American Heart Association.
Prophylaxis and treatment
The prophylactic treatment is penicillin, which is essential to preventing heart disease. Penicillin remains the drug of choice to prevent infection, treat the inflammatory process and continue long-term prophylaxis.
Prognosis
Cardiac involvement will mark the long-term prognosis. Arthritis, chorea and cutaneous lesions are self-limited. The forecast is given by the degree of cardiac involvement and valvular lesions residual.
Posted Aug 1, 2017 by MelanieMolina 2050
