Scleroderma can cause depression as can any other disappointment in life. It comes from losing abilities or being sad about the state of limited life expectancy or living with weakened state. It is easy to say, "Chin up, it will get better," but someone with depression cannot 'snap out' of true depression. It requires professional help from knowlegeable professionals. It may require medication. Scleroderma, or any other disease, disorder, or limitation might affect one's mood. Forgive youself and seek help.