The absolute worst symptom of APS is Stroke. Blood clots can and do cause Strokes, and they can occur at any age, and at any time and they don't care if you are male, female. I have been blessed to survive 4 major strokes and five minor strokes, I have lost most of my vision due to one stroke, had to relearn how to walk, talk, read and write after 2 of them, I have also survived multiple TIA's and DVT's, due to clots