Short answer · Medically reviewed summary · Last updated: 2026-04-07
Factor V Leiden is an inherited thrombophilia, most commonly referred to by its clinical name, Factor V Leiden mutation, or simply as FVL. Common Synonyms and Abbreviations While Factor V Leiden is the standard term used globally, you may encounter it under several variations in medical literature or your own health records. Common synonyms include: Activated Protein C Resistance (APCR) – This refers to the laboratory finding often caused by the mutation. Factor V R506Q – A technical designation reflecting the specific amino acid substitution. FVL mutation Inherited thrombophilia (a broader clinical category) Historical and Classification Context The name Factor V Leiden was coined in 1994, named after the city of Leiden in the Netherlands, where researchers first identified the specific genetic defect.
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Factor V Leiden synonyms
Other names for Factor V Leiden: synonyms, acronyms and related terms used by doctors and patients.
Factor V Leiden is an inherited thrombophilia, most commonly referred to by its clinical name, Factor V Leiden mutation, or simply as FVL.
Common Synonyms and Abbreviations
While Factor V Leiden is the standard term used globally, you may encounter it under several variations in medical literature or your own health records. Common synonyms include:
- Activated Protein C Resistance (APCR) – This refers to the laboratory finding often caused by the mutation.
- Factor V R506Q – A technical designation reflecting the specific amino acid substitution.
- FVL mutation
- Inherited thrombophilia (a broader clinical category)
Historical and Classification Context
The name Factor V Leiden was coined in 1994, named after the city of Leiden in the Netherlands, where researchers first identified the specific genetic defect. Before this discovery, patients experiencing unexplained clots were often grouped under generic diagnoses like "familial thrombophilia." In major medical classification systems, it is indexed as follows:
- OMIM (Online Mendelian Inheritance in Man): #612309 (Factor V Leiden)
- Orphanet: ORPHA98877
- ICD-10: D68.5 (Congenital thrombophilia)
Why Multiple Names Exist
The existence of multiple names for Factor V Leiden arises from the difference between the clinical manifestation (thrombophilia), the laboratory test (APCR), and the genetic cause (the F5 gene mutation). Medical professionals generally prefer the term Factor V Leiden because it is specific, widely recognized, and avoids confusion with other forms of inherited clotting disorders. When reviewing your records, if you see "APCR" or "FVL," they are almost certainly referring to the same condition that increases the risk of developing clots in the legs, arms, or lungs.
Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always seek the advice of your hematologist or primary care physician regarding your specific health condition and clinical test results.
References
- NIH Genetic and Rare Diseases Information Center (GARD): Factor V Leiden thrombophilia
- Orphanet: Factor V Leiden
- OMIM: Factor V Leiden; FVL
Some clots do no damage and disappear on their own. Others can be life-threatening. Symptoms of a blood clot depend on where it forms and whether and where it travels.
Posted Dec 28, 2017 by Barbara 4050
