How do I know if I have Multiple Systems Atrophy?

Multiple Systems Atrophy (MSA) is a rare, progressive neurodegenerative disorder that typically presents with a combination of autonomic dysfunction, such as orthostatic hypotension, and motor symptoms similar to Parkinson’s disease. Because symptoms vary widely, diagnosis requires a thorough evaluation by a neurologist to distinguish Multiple Systems Atrophy from other movement disorders.

What are the early signs of Multiple Systems Atrophy?

Early indicators of Multiple Systems Atrophy often involve the autonomic nervous system before motor symptoms become prominent. Patients frequently report significant dizziness upon standing (orthostatic hypotension), unexplained urinary urgency or retention, and erectile dysfunction in men. These may be accompanied by subtle changes in movement, such as slowness (bradykinesia) or stiffness, which might initially be mistaken for common aging or other conditions.

How can I identify patterns in my health?

Monitoring your symptoms can provide valuable data for your physician. Look for these specific patterns often associated with Multiple Systems Atrophy:

• Autonomic changes: Frequent lightheadedness when rising from a chair or bed.


• Motor shifts: Difficulty with balance, frequent falls, or one-sided muscle weakness.


• Respiratory concerns: Unusual high-pitched breathing sounds during sleep, known as stridor.


• Sleep disturbances: Central sleep apnea or disrupted sleep architecture.

When should I see a doctor and what tests are used?

If you notice a cluster of these symptoms, schedule an appointment with a neurologist. When you speak with them, specifically mention your concerns regarding autonomic failure and motor control. Diagnostic investigations for Multiple Systems Atrophy often include:

1. Autonomic testing (e.g., tilt-table test) to measure blood pressure response.


2. MRI of the brain to look for specific "hot cross bun" signs or atrophy in the cerebellum.


3. Urodynamic studies to assess bladder function.


4. Polysomnography to evaluate breathing patterns during sleep.

Next steps

• Keep a detailed symptom diary to share with your specialist.


• Join the 911 members of the DiseaseMaps.org community to share experiences and find support.


• Seek a second opinion from a movement disorder specialist if your symptoms persist without a clear explanation.

Medical Disclaimer: This information is for educational purposes and does not replace professional medical advice, diagnosis, or treatment.

References

• NIH Genetic and Rare Diseases Information Center (GARD): Multiple System Atrophy.


• Orphanet: Multiple System Atrophy (ORPHA:587).


• OMIM (Online Mendelian Inheritance in Man): Entry #146500.


• The MSA Coalition: Understanding the clinical presentation of Multiple Systems Atrophy.